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pentobarbital will decrease the level or outcome of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.pentobarbital increases toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may boost the metabolism of ifosfamide to its Lively alkylat